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Sciences indexed since 1998 submit story | join | login   view all biology business chemistry engineering geography health mathematics society   all     medullary thyroid carcinoma (mtc) and ret proto-oncogene: mutation spectrum in the familial cases and a meta-analysis of studies on the sporadic form submitted by mgonond 11 hours ago medullary thyroid carcinoma (mtc) is an uncommon malignant tumor arising from the calcitonin-producing parafollicular cells (c cells) of thyroid. It accounts for 5-10% of all thyroid cancers, and it mostly occurs as a sporadic entity (smtc), but a familial pattern (fmtc) is also possible. Ret proto-oncogene germline mutations are crucial for the onset and the progression of fmtc, and the occurrence of single nucleotide polymorphisms could predispose to the sporadic form. In order to clarify the role of this gene in mtc, we carefully reviewed the pubmed database using appropriate terms. Viagra online ireland First, we summarized current knowledge of the germline ret mutations, mutation spectrum, and prevalence. We then performed a meta-analysis on the available case-control association studies for smtc. Finally, we carried out in silico predictions of the best associated variants in the attempt to better define their role in the disease. To date, a total of 39 different ret germline mutations have been identified in fmtc families. The most affected codons are 609, 611, 618, 620 (exon 10) and 634 (exon 11), encoding for the extracellular cysteine-rich domain, and codons 768 (exon 13) and 804 (exon 14) of the intracellular tyrosine kinase domain. viagra online auto Six polymorphisms with at least three studies were included in the meta-analysis (a45a [rs1800858], g691s [rs1799939], l769l [rs1800861], s836s [rs1800862], s904s [rs1800863], and ivs1-126g> t [rs2565206]). The meta-analysis demonstrated a modest association of smtc susceptibility with s836s and a strong association with the ivs1-126g> t polymorphism. Besides ret polymorphisms, we also investigated the role of a few other low-penetrance alleles of genes involved in the ret pathway or in xenobiotic metabolism, but none of these were confirmed. Thus, despite the well-known molecular basis of fmtc, the genetic variants of the sporadic form are still poorly understood, and functional analyses are needed to better understand the consequence of such ret variants and to improve our knowledge on the disease. viagra online auto 1 dig(s) dig it bury topic: genetics comments (0) who dugg this story? Email this link add your comment please login or signup to leave a comment related stories combined ret and ki-67 assessment in sporadic medullary thyroid carcinoma: a useful tool for patient risk stratification submitted by mema238 1 year and 4 months ago medullary thyroid carcinoma (mtc) derives from the parafollicular c cells, being sporadic in 75% of cases and familial in 25%, due to ret proto-oncogene germinal mutations. In sporadic forms, stage at diagnosis is the most important negative prognostic factor. The aim of this study was to evaluat... Buy viagra japan   1 dig(s) dig it bury topic: endocrinology multiple endocrine neoplasias type 2b and ret proto-oncogene submitted by foizihkofe 3 months ago multiple endocrine neoplasia type 2b (men 2b) is an autosomal dominant complex oncologic neurocristopathy including medullary thyroid carcinoma, pheochromocytoma, gastrointestinal disorders, marphanoid face, and mucosal multiple ganglioneuromas. Medullary thyroid carcinoma is the major cause of m...   1 dig(s) dig it bury topic: health somatic ras mutations occur in a large proportion of sporadic ret-negative medullary thyroid carcinomas and extend to a previously unidentified exon submitted by oenat 2 days ago medullary thyroid carcinoma (mtc) is characterized by proto-oncogene ret mutations in almost all hereditary cases as well as in more than 40% of sporadic cases. viagra online auto Recently, a high prevalence of ras mutations was reported in sporadic mtc, suggesting an alternative genetic event in sporadic mtc tumor... 100mg viagra for sale   1 dig(s) dig it bury topic: endocrinology novel ret germline variants in exons 8 and 11 display an oncogenic potential in vitro submitted by kallir 2 years and 6 months ago most germline-activating mutations of the ret proto-oncogene associated with inherited medullary thyroid cancer (mtc) are localized in exons 1, 11 and 13–15. Four novel ret variants, located in the extracellular domain (p. A51v, p. E511k and p. viagra online auto C531r) coded by exon 8 and in the intracellular j...   1 dig(s) dig it bury topic: endocrinology clinical spectrum of men2a in a large family caused by the infrequent ret mutation cys69phe submitted by micdean 3 months ago mutations in ret proto-oncogene cause multiple endocrine neoplasia 2a (men 2a). Mutations in codons 69 and 611 are not frequent. We identified two men2a families with the cys69pheret mutation, which turned out to be the same family. Order viagra online australia This mutation has been described a couple of times with no clini... viagra online auto   1 dig(s) dig it bury topic: anatomy drug therapy for hereditary cancers submitted by sinteno 1 year and 2 months ago tumors arising in patients with hereditary cancer syndromes may have distinct drug sensitivity as compared to their sporadic counterparts. Breast and ovarian neoplasms from brca1 or brca2 mutation carriers are characterized by deficient homologous recombination (hr) of dna,. Buy generic viagra review

Who We Are

The Papers of Abraham Lincoln is a long-term project dedicated to identifying, imaging, transcribing, annotating, and publishing all documents written by or to Abraham Lincoln during his entire lifetime (1809-1865).

Grant will help safeguard images of Lincoln papers

Papers of Abraham Lincoln receives ‘AWS in Education Grant’ to store images in secure environment

September 3, 2013

SPRINGFIELD – The Abraham Lincoln Presidential Library and Museum announced today that Amazon Web Services has awarded the Papers of Abraham Lincoln an “AWS in Education Grant” of $24,000 in storage services. This will allow the Papers of Abraham Lincoln to store more than 35 terabytes of master image files in a secure environment.

For the past decade, the staff of the Papers of Abraham Lincoln has been collecting images of documents written by or to Abraham Lincoln from repositories and private collections around the world. The project has scanned more than 90,000 documents from more than 400 repositories and 180 private collections in 47 states and 5 foreign countries thus far. The archive will likely top 150,000 documents when complete.

From 2006 to 2013, the National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign housed the growing archive of master image files. The retirement of their Mass Storage System has forced the project to look for a new storage solution for its 35 terabytes of files. (Thirty-five terabytes is roughly equivalent to a digital music file that would play non-stop for 68 years, or to 10.8 million photographs.)

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  • Lincoln 1863

    Lincoln in 1863

  • Gettysburg Address

    One of the five extant copies of the Gettysburg Address.  Courtesy of the White House Historical Association.

  • Lincoln 1864

    Lincoln in 1864.

  • Lincoln endorsement

    Lincoln endorsement discharging an under-age soldier, November 1863.  Courtesy of a private collector.

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